antimony trioxide cancer

Being methodologically sound, this study is deemed supportive (S). It is i2as view that the results of the US NTP Carcinogenicity studies published in 2017 do not change the above self-classifications. Consider reading this Proposition 65 Fact Sheet about how to reduce your exposure to antimony trioxide. It may naturally appear in oxidation states of III, 0, +III, or +V with Sb (III) being more stable than Sb (V). 2020 Nov 26:oemed-2020-106980. Only male animals were studied in the liver DNA repair assay. Afterwards, evidence was integrated in the separate data streams and finally integrated across data streams. The International Agency for Research on Cancer has determined that antimony trioxide is possibly carcinogenic to humans and that antimony trisulfide is not classifiable. In PubMed, we used the search terms (Occupational Exposure [Mesh] OR work* [All Fields]) AND (antimony used the search terms (Occupational Exposure [Mesh] OR work* [All Fields]) AND (antimony [Mesh] OR antimony [All Fields]) AND (Neoplasms [Mesh] OR cancer [All Fields] OR canc* [All Fields]) on 28 June 2018 and this search yielded 26 hits. The promotion on cell growth of androgen-dependent prostate cancer by antimony via mimicking androgen activity. doi: 10.1371/journal.pone.0170869. Some of these exposures (arsenic, cobalt, asbestos, smoking, and polycyclic aromatic hydrocarbons (PAHs)) are known causes of cancer. In 2018 the US NTP published its revised draft Report on Carcinogens (RoC) Monograph on Antimony trioxide. We investigated the cancer hazard of antimony compounds for workers, a population with high exposure to antimony substances. Poon R., Chu I., Lecavalier P., Valli V.E., Foster W., Gupta S., Thomas B. 1Department of Public Health and Primary Care, Centre Environment & Health, 3000 Leuven, Belgium; eb.nevueluk.tneduts@snereas.notna (A.S.); eb.nevueluk@hsohg.jisonam (M.G. Antimony trioxide, technical - is a chemical raw material used as a flame retardant and a binder in the polymer processing industry and rubber components. About Aldehydes. . In 1989, the International Agency for Research on Cancer (IARC) published the Monograph on antimony trioxide and antimony trisulfide. DNA repair could be impaired through antimony by the inhibition of nucleotid excision repair (NER) through the interaction with a zinc finger domain [48] and by the inhibition of a double stranded break (DSB) repair (a non-homologous end joining (NHEJ) as well as homologous recombination (HR)) [49]. The https:// ensures that you are connecting to the Based upon predominantly inhalation studies, lung cancer is the most probable adverse effect on which data exist in humans and animals and has a very high severity. As sex differences in animal studies were observed and background exposure between both sexes may differ, data in men are not to be readily extrapolated to women. Most of the available health effects data are for trivalent antimony compounds which appear to be more Gerhardsson 1982 [37] and 1993 [25] were case-control studies. This is contrary to arsenic, a similar semimetal chemical [13] that has been established as a carcinogen. Antimony Trioxide Price and China Ato, Flame Retardant Zinc Borate, Zinc Carbonate Basic products are commonly for chemical use. Precautionary Statements Prevention: Obtain special instructions before use. Background Document for Development of WHO Guidelines for Drinking-Water Quality. Contact Supplier Antimony Trioxide 450 / Kilogram Goyal Chemicals Contact Supplier One of the reasons for this could be the relatively low use of antimonials in industrial applications [14]. Top of Page The substances most studied are antimony trioxide in inhalation [16,21,41,42], ingestion [33,34,42,43], and dermal contact studies [16] as well as antimony potassium tartrate, only in oral ingestion via food or water [31,44,45,46]. COA: Please Contact Genprice for Certificate of Analysis. Bethesda, MD 20894, Web Policies In human lung tissue, a very long biological half-life (more than 600 days) is assumed, based on a study with accidental exposure to Sb-125 [10]. Vlaanderen: 052 37 41 21 Wallonie: 080 44 79 58. [(accessed on 8 September 2018)]; Verdugo M., Ruiz Encinar J., Costa-Fernndez J.M., Menendez-Miranda M., Bouzas-Ramos D., Bravo M., Quiroz W. Study of conformational changes and protein aggregation of bovine serum albumin in presence of Sb(III) and Sb(V). Studies investigating genotoxic and clastogenic effects of antimony have been reviewed elsewhere [14] and are briefly mentioned here. Paint manufacturers use Antimony Oxide as a white pigment. Noting that the aim of chemicals classification is to inform and protect humans, none of the results of the US NTP studies indicate that the current self-classification would be insufficiently informative or protective. Before No difference in mitotic indexes between exposed groups and unexposed groups; chromosomal abberations in Sb2O3 treated groups were low (falling within normal ranges) and not significantly higher than in vehicle controls; Micronucleated polychromatic erythrocytes (MNPCE): % PCE not reduced in Sb2O3 treated groups as compared to vehicle control; MN frequencies in Sb2O3 exposed groups within normal ranges and not significantly different from vehicle control groups, NOAEL for MNPCE and CA: 1000 mg/kg food dose, Two years, 5 d per week, 6 hper day, with interim sacrifice at 6 and 12 months, Significant increase in benign fibrous histiocytoma and fibrous histiocytoma/fibrosarcoma (, LOAEL for male mice and NOAEL for female mice: 30 mg/m. Given the potential occupational health hazard identified in the previous sections, an occupational health risk assessment is warranted. Koch B., Maser E., Hartwig A. Articles were then critically appraised (risk of bias assessment) and evidence in occupational and animal settings separately integrated. Glass manufacturers use it as a fining agent or as degasser (to remove bubbles). Zhang 2018 [26] had already been excluded after discussion of other search results. The antimony oxide is inside the camera in minuscule amounts. 1987;13:412416. Antimony Trioxide CAS Number 1309-64-4 Synonym Antimony sesquioxide; Antimonous oxide; Antimony oxide, Oxo-oxostibanyloxystibane; Diantimony trioxide Occurrence/Use Component of flame retardant treatment for polymers; opacifying agent for glasses, ceramics, and enamels; specialty pigments; naturally occurring as valentinite and senarmontite These can be found in Supplementary Material Table S2. The reviewers agreed to include 2 articles from the first PubMed search and 10 articles from the first ToxLine search. Methodologically, it is robust, peer reviewed, and described in profound detail. Lastly, when considering findings of this review, two nuances should be kept in mind, the former concerning sex and the latter concerning study goal. Toxicol. Schroeder H.A., Mitchener M., Nason A.P. Data from this review were applied in a human health risk assessment. Company: Angstrom Sciences, Inc. 40 South Linden Street . The major drivers for this market are increasing safety and security measures for smoke and flammability and growth in end use industries such as construction and electrical & electronics. Sb2O3 was classified as possibly carcinogenic to humans (Group 2B), Sb2S3 was not classifiable as to its carcinogenicity to humans (Group 3) [15]. Another industry for chemical usage is Clothing. Wet and dry weights of the liver, kidney, and lungs of animals receiving the 500 mg Sb /kg diet were not significantly different from those of control animals. Whether or not this implies a tightening of threshold levels remains an open question based on the available evidence. We finally used the search terms described below. One last important point to keep in mind is the possibility that carcinogenic effects of antimony are attenuated, augmented, or only present when concomitant exposure to other substances exist [54] For instance, such an interaction appears to exist between arsenic and antimony [55] or could be the case for selenium and antimony [25]. (1) The chemical symbol for antimony is Sb, and it has an atomic weight of 121.75 g/mol. Overall, carcinogenicity in workers is probable (International Agency for Research on Cancer (IARC) 2A). Health. Persistent dose-dependent histological changes in thyroid gland, perisistent dose dependent histological changes in liver (irreversible after 4 wk recovery period), very mild treatment-related changes in spleen developing predominantly in recovery period; changes in thymus in recovery period; minimal non-dose dependent changes in pituitary gland. Sb(+V) can be reduced to Sb(+III) and conjugated with glutathione and to a higher degree, Sb(+III) is oxidized into Sb(+V) [10,11]. Zhang C., Li P., Wen Y., Feng G., Liu Y., Zhang Y., Xu Y., Zhang Z. Antimony Trioxide is an inorganic compound predominantly utilized as a flame-retardant synergist for plastics, paints, rubber, electronics, and textiles. In the Watt [21] paper, one of the major concerns is its potential confounding. Antimony can be measured in the urine, The U.S. National Toxicology Program (NTP) concluded that antimony trioxide "is reasonably anticipated to be a human carcinogen based on studies in rats and mice". 1.8. Exposed animals were mice, rats, and voles. Among the studies deemed informative, some studies (Sweeney [22], Wingren [5,23], and Finkelstein [39]) found an increase in lung cancer as well. The CLP Regulation makes sure that the hazards presented by chemicals are clearly communicated to . The recent NTP Report on Carcinogens Monograph on Antimony Trioxide [9] found that there is sufficient evidence of the carcinogenicity of antimony trioxide in experimental animals. Proposition 65 requires businesses to determine if they must provide a warning about significant exposure to No other study found similar effects. All 4 were eventually excluded based on the exclusion criteria: Zhang 2018 [26] was no pure animal study because it studied human prostate cancer cells (LnCaP) implanted in mice, Kotsopoulos 2012 [27] was no animal study, Rossi 1987 [28] had uncertain relevance to health endpoint, and Sunderman 1983 [29] met exclusion criterion intramuscular administration. Centers for Disease Control (CDC) National Biomonitoring Program: Biomonitoring Summary. Effects were only seen in 407 mg/kg group: Clinical signs of toxicity: impaired weight gain, rough haircoat, emaciation, abnormal posture, hypoactivity, and decreased fecal material, consistent with avoidance of the APT-dosed water. about navigating our updated article layout. Effects of Antimony on Rice Growth and Its Existing Forms in Rice Under Arbuscular Mycorrhizal Fungi Environment. The authors saw non-dose dependent changes in the pituitary gland. government site. This is most probably aimed at evaluating the results of the US NTP carcinogenicity studies published in 2017. i2a has determined the applicable classification for 10 Antimony substances following the UN Globally Harmonized System (GHS) criteria. blood after several days or weeks, depending on the antimony compound. Secondly, interconversion is possible in the environment [9] as well as in vivo (see Toxicokinetics section below). Call CDC-INFO at 1-800-232-4636, or submit your question online at Garg S.P., Singh I.S., Sharma R.C. Federal government websites often end in .gov or .mil. https://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB. The antimony oxide promotes the formation of "char" (essentially carbon) on the substrate which reduces volatile gas formation. We consider the animal research by NTP [16] key (K) in this review. A cancer assessment for antimony trioxide is not available on IRIS (U.S. EPA, 2008) or in the HEAST (U.S. EPA, 1997). Work Environ. Antimony trioxide was last classified by the International Agency for Research on Cancer (IARC) in 1989 as Group 2B, possibly carcinogenic to humans, based on inadequate evidence in humans and sufficient evidence in animals. Referents: rural referents (farmers, forestry workers,). 2022 Sep 12;10:963138. doi: 10.3389/fpubh.2022.963138. FOIA 6 h/day, 5 d/week for 52 weeks followed by 52 week postexposure period, Increase in potential* preneoplastic lung lesions related to exposure: chronic interstitial inflammation in highest exposure group (, two years, 5 d per week, 6 h per day, with interim sacrifice at 6 and 12 months, In lung tissue: Alveolar/bronchiolar adenoma or carcinoma: no significant difference; Alveolar/bronchiolar carcinoma: no significant difference; Alveolar/bronchiolar adenoma no significant difference. In the informative study by Groth [41], antimony ore concentrate induced lung neoplasms in female rats. effects have been reported, including heart problems, Workers live longer and can be exposed for longer than 2 years. Non-exposure or exposure beneath threshold that produces critical effect, Development of any type of premalignant lesion, cancer, or malignancy, Metal smelting and refinery (Sb species not specified), Cases: deceased men in northern Sweden, and who died during the period 1976- 1978, divided into 3 groups (I: death caused by malignancy, II: death caused by cardiovascular disease III: death from other causes); Controls: age-matched men from a town 50 km from the factory, Cases: 40 (I: 15, II: 17, III: 8); Controls: 11, Not measured, instead tissue concentrations were measured, Duration of employment, interindividual differences. ; project administration, A.S. However, that study found no relationship between urinary excretion of antimony and lung cancer, possibly because exposure doses in general populations may not attain carcinogenic levels. Disclaimer, National Library of Medicine Read-across and weight of evidence is furthermore applied to predict the properties of those forms of Antimony which have had fewer studies carried out on them. HHS Vulnerability Disclosure, Help Industrial exposure thresholds have been formulated. A small amount of the antimony that you eat or drink enters the blood after a few hours. 95 %, extra pure. ; resources, A.S.; data curation, A.S., M.G. Related to this, it is worth noting that most studies are mortality studies, in which findings are based on mortality causes. 497506. This naturally occurring metal is combined with lead, zinc, tin, and other metals to make metal alloys. Kbg3_Ctp.!,pH)zax:exJ&^Ii@zARA:wA]>W+\7|Ac [. to pass through the lining of the lungs and enter the bloodstream. in blood sugar levels, and developmental effects (decreases in growth) have been found in animals The resulting self-classifications (Table 1 below) are reported in the REACH dossiers, recommended to the value chain, and reviewed whenever necessary (e.g. Data on toxicokinetics of antimony are scarce and research predominantly involves pentavalent antimonials in parenteral treatment of parasitic diseases. Mutat. The goal of this study is twofold. Limited confidence in comparison groups is the major drawback of that paper. Antimony trioxide Antimony white Antimony(3+) oxide Antox Anzon-TMS Blue Star C.I. b3IU U]VEi@` hBg` e Distribution, source, water quality and health risk assessment of dissolved heavy metals in major rivers in Wuhan, China. In 2016, the USs National Toxicology Program (NTP) finalized its animal toxicology studies on inhalation exposure to antimony trioxide, concluding that antimony trioxide causes lung neoplasms in both sexes of mice and rats [16]. https://wwwn.cdc.gov/TSP/ToxProfiles/ToxProfiles.aspx?id=332&tid=58, Go to ATSDRs Toxic Substances Portal: It was however calculated afterwards by NTP [9]. It is used as a metal alloy and as medicinal and. Schroeder H.A., Kanisawa M. Life term studies on the effect of trace elements on spontaneous tumors in mice and rats. https://www.atsdr.cdc.gov/DRO/dro_org.html. Based on animal studies, estimates of probability of lung cancer for exposed vs. non-exposed groups were elevated for mice but not for rats. We investigated the cancer hazard of antimony compounds for workers, a population with high exposure to antimony substances. Schroeder 1970 [45] suffers from similar methodological drawbacks [31]. 2.3. Lesions considered preneoplastic (e.g., alveolar/bronchiolar hyperplasia) were seen in both sexes. Fifth, it is unclear whether latency times for cancer manifestation were sufficiently accounted for. Antimony (Sb) is a chemical which resides in the group of semimetals. Guidelines for performing systematic reviews in the development of toxicity factors. Sweeney M.H., Walrath J., Waxweiler R.J. Mortality among retired fur workers. An official website of the United States government. NOAEL 20,000 mg/kg food exposure monodose, Chromosomal abberations: chromatid gaps, chromatid breaks, centric fusions and polyploidy in bone marrow cells. 58802 Balve, Germany Chemische Fabrik Wocklum Gebr. Genet. Gurnani N., Sharma A., Talukder G. Cytotoxic effects of antimony trichloride on mice in vivo. Dyers, dressers (tanners) and service workers. Careers. Today, these effects still apply, as exposure to antimony may cause gastrointestinal symptoms like nausea, vomiting, anorexia, abdominal pain, and stomach ulcers. Genotoxicity studies conducted to elucidate mechanism(s) for tumor induction have produced mixed results. It got the highest ROB score. Prevent children from eating or playing in dirt if you live near a waste site contaminated with antimony. In the 21d exposure groups, dose dependent chromosomal abberations were seen for both sexes (, Chromosomal abberations in bone marrow cells, Frequencies of chromosomal aberrations (DNA strand breaks principally) were directly related to the dose used and were significantly higher than the control. An overview of our study design can be found in Table 2. No positive control was used, as is now standard practice in clastogenicity studies [33]. Gebel T. Suppression of arsenic-induced chromosome mutagenicity by antimony. Antimony trioxide CASRN 1309-64-4 | DTXSID4023880 IRIS Summary (PDF) (21 pp, 158 K) Key IRIS Values; Other EPA Information; Noncancer Assessment. Conclusions: Antimony carcinogenicity evidence involving workers is inadequate, based on confounding, small sample sizes, incomparability across studies, and inadequate reference populations. Two separate data streams were established, the first being the human (occupational) toxicology stream and the second being the animal toxicology stream. 41000 , China changsha yaguang economic and trading co., ltd. Request a callback. The primary goal (like the IARC Monographs and unlike regulatory substances [53]) of this study was to identify a potential hazard for occupational exposure to antimony species. Therefore, a potential for malignant transformation is greater. Reference Dose for Oral . More harmonized internal and external exposure data for humans is needed to determine levels from which carcinogenic effects arise. Regarding PubMed articles, there was a discussion about 4 more articles (Zhang 2018 [26], Kotsopoulos 2012 [27], Rossi 1987 [28], and Sunderman 1983 [29]). Relevance to carcinogenesis in vivo in rodents and humans is unclear. Gerhardsson L., Nordberg G.F. not known to cause health effects. 0 Antimony Trioxide. Scand. In the studies rated highest (key/supportive and supportive), an increased lung cancer mortality was a recurrent finding. Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. these studies have tested doses that are higher than levels found in the environment. It hence recommends the listing of Antimony trioxide on the RoC. Hazard classification & labelling Hazard classification and labelling The 'Hazard classification and labelling' section shows the hazards of a substance based on the standardised system of statements and pictograms established under the CLP (Classification Labelling and Packaging) Regulation. This research received no external funding. We started with the development of the search string for Medline and subsequently adapted key words to better fit in ToxLine. This study concluded that the substance induces chromosomal aberrations in bone marrow cells [20]. Trivalent antimony is excreted mainly through feces via biliary ways, whereas pentavalent antimony is mainly excreted in urine [1]. Histopathological signs: in forestomach: necrosis, ulceration, inflammation and focal hyperplasia of squamous epithelium; in hepatocytes: centriblobular cytoplasmic vacuolization. Air Resources Board; Cal Recycle; Department of Pesticide . Appearance: As specified on the SDS. The flame retarding action is thought to take place in the vapor phase above the burning surface. Sb2O3. 8600 Rockville Pike Transient irritating skin rashes called antimony spots arise when workers are exposed to antimony in hot weather. 19401992 (study enrollment and follow-up period); split into two groups (before and after 1961), Average levels of air contamination: 0,00050,11 mg/m3. antimony trioxide has been detected in the lungs, blood and urine of workers in occupational settings where antimony is processed, and biomonitoring data indicate that antimony compounds are retained postinhalation exposure. One way to learn about whether antimony will harm people is to conduct studies in lab animals. Online ahead of print. International Agency for Research on Cancer (IARC) - Summaries & Evaluations ANTIMONY TRIOXIDE AND ANTIMONY TRISULFIDE Antimony trioxide (Group 2B) . City Chemical manufactures high purity Antimony Trioxide, CAS 1309-64-4 in bulk quantity. FOIA For stomach cancer, Wingren [4,5] saw contradictory effects. The authors declare no conflict of interest. Zhou M, Li X, Liu X, Mi Y, Fu Z, Zhang R, Su H, Wei Y, Liu H, Wang F. Front Microbiol. Antimony trioxide is a chemical under study by ACGIH and may move forward with a Notice of Intended Change (NIC) proposal in 2019. when new evidence becomes available, for example following an evaluation process). feces, and blood for several days after exposure. In animal studies, we characterized the following wherever possible: Antimony compound, study animal, sample size, route of exposure, dose of exposure, duration of exposure, principal findings, and LOAEL/NOAEL where possible. Randomization was questioned in the NTP Monograph [9]. WARNING: This product can expose you to antimony trioxide, which is known to the State of California to cause cancer. National Toxicology Program (NTP), N.I. Available research did not permit a broader evaluation. OR (with 90% CI) for colon cancer were correlated with exposure: no exposure to antimony 1.4 (0.63.3) low exposure 1.8 (0.813.8) high exposure 5.0 (2.69.6); no excess risk for lung cancer and a decrease in stomach cancer risk were seen (no significance level reported). ; writingoriginal draft preparation, A.S.; writingreview and editing, M.G., L.G., and J.V. In PubMed, we first used the search terms (antimony [Mesh] OR antimony [All Fields]) AND (Neoplas* OR cancer [All Fields] OR carcinog* [All Fields]) NOT (sentinel OR leishman* OR schistosom*). A pooling of remaining articles from both search engines resulted in 10 articles with full-text access. The site is secure. When you breathe air containing antimony, antimony particles can be deposited in your lungs. Carcinogenesis tests of Nickel Arsenides, Nickel Antimonide, and Nickel Telluride in rats. Cookies used to make website functionality more relevant to you. Duquesne, PA 15110 . Weight of Evidence for Cancer (PDF) (21 pp, 158 K) Not assessed under the IRIS Program. SDS: Please Contact Genprice for SDS. The Profile is impressive from the standpoint of the encyclopedic citation of scientific studies dating back 60 or more years. Plasma micronutrients, trace elements, and breast cancer in BRCA1 mutation carriers: An exploratory study. The relative risk for exposed mice was around five, depending on exposure group [16]. Individual studies involved different industries (metal mining vs. metal refinery vs. glass production); Exposure dose and duration measurements of antimony and other (potential carcinogenic) substances are incomplete. **(50% dead males: 582 days, 90% dead males: 651; 50% dead females: 576 days, 90% dead females: 742 d), 51 male and 59 female rats (antimony group) and 52 male and 54 female rats (control group), Survival time and development of grossly visible tumors, Survival time reduced in antimony fed rats (on average 106 d less for male and 107 d less for females). /Genet. The amount and In this monograph, it concludes that Antimony trioxide can reasonably be expected to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals and supporting data from mechanistic studies. 2021 Jul 27;9:e11853. Porcelain and Enameling services use it as an opacifier. 2022 Mar 22;13:814323. doi: 10.3389/fmicb.2022.814323. The listing of Antimony trioxide on the RoC will not send the right signal or provide the right level of information to the producers and users of Antimony trioxide. %PDF-1.7 % After systemic absorption, antimony is distributed to the erythrocytes, liver, kidney, spleen, bone, lung, and thyroid tissue. In its positive pentavalent form, it may be a part of antimony pentafluoride or antimony pentachloride [1]. Therefore, this study is rated informative (I). medical reasons. Accessibility In the NTP [16] key study, antimony trioxide induced lung adenoma, lung carcinoma, and lung lesions which are considered preneoplastic (e.g., alveolar/bronchiolar epithelium hyperplasia) in male and female mice. It is brought into this country from other countries for processing. However, these tests cannot tell you how much antimony Tarazona J.V., Court-Marques D., Tiramani M., Reich H., Pfeil R., Istace F., Crivellente F. Glyphosate toxicity and carcinogenicity: A review of the scientific basis of the European Union assessment and its differences with IARC. In the acute exposure groups, no clastogenic effects were seen. Kirkland D., Whitwell J., Deyo J., Serex T. Failure of antimony trioxide to induce micronuclei or chromosomal aberrations in rat bone-marrow after sub-chronic oral dosing. Cal EPA. It is thought that the trivalent form is more active in vivo [2]. Hazardous Substances Data Bank. Moreover, their sample was struck by a pneumonia epidemic causing premature death. For inhalation, the American Conference of Governmental Industrial Hygienists (ACGIH) put the threshold limit value (TLV) for an eight-hour time weighted average (TWA) on 0.5 mg/m3 (antimony compounds in general, including antimony trioxide) and 0.1 mg/m3 (stibine) [17]. Overall, this study is considered informative (I). Consequentially, we can conclude that risk of cancer cannot be excluded in current real-life working conditions, especially in workers with the highest exposures, and thus further scrutiny is warranted. Exposure to antimony trioxide may increase the risk of cancer. Jones R. Survey of antimony workers: Mortality 19611992. This search yielded 117 hits on 28 June 2018. Antimony trioxide is a compound produced from antimony, a lustrous gray metalloid, or naturally occurring antimony-oxide containing minerals. ; validation, A.S., M.G., L.G., and J.V. The study types were predominantly retrospective occupational cohorts [4,5,23,35,38,39,40]. https://wwwn.cdc.gov/TSP/ToxProfiles/ToxProfiles.aspx?id=332&tid=58, https://www.atsdr.cdc.gov/DRO/dro_org.html, Agency for Toxic Substances and Disease Registry, U.S. Department of Health & Human Services. Exposure doses varied widely and exposure duration ranged from single gift to two years to lifelong exposures of more than 2.5 years. Zirconium, Niobium, Antimony, Vanadium and Lead in rats: Life term studies. will also be available for a limited time. It remains unclear from what occupational exposure duration and dose this effect arises and whether exposure threshold values should be reconsidered. STOT SE 3 H335 if C 5%, Avenue de Tervueren 168, Box 6 | 1150 Brussels | Belgium | Tel. This environmental exposure always is a combination of several antimony compounds. We did not perform an extensive mechanistic search, given the research question primarily involves workers. This conclusion is based on an observed increase of lung cancer cases and preneoplastic lung lesions in exposed animals in a key study, reinforced by supportive and informative studies. Antimony is used for lead production. Hepatobiliary cancer mortality was increased in the key/supportive study by Schnorr [38] with a SMR of 3.17 (p < 0.05) and 1.58 (p > 0.05), depending on the reference population. Like most polymeric oxides, Sb2O3 dissolves in aqueous solutions with hydrolysis. Antimony in your lungs will enter your No obvious harmful effects: The appearance of the internal organs of voles receiving the 500 mg Sb/ kg diet was indistinguishable from that of the control voles. The evidence for carcinogenicity (lung neoplasms) of antimony inhalation as a trioxide in experimental animals is sufficient. Gurnani N., Sharma A., Talukder G. Comparison of clastogenic effects of antimony and bismuth as trioxides on mice in vivo. Antimony is a silvery-white metal that is found in the earths crust. No histological changes compared to control group voles could be observed in the sections of liver and kidney examined by electron microscopy. antimony trioxide Lab Grade from Genprice. This excess was observed as well in the informative study by Finkelstein [39]. Hazard Statements: H351 Suspected of causing cancer TLVs and BEIs Based on the Documentation of the Threshold Limit Values for Chemical Substances and Physical Agents & Biological Indices. Some possible mechanisms have been identified. In 1989, the International Agency for Research on Cancer (IARC) concluded that Diantimony Trioxide is possibly carcinogenic to humans (Group 2B), and Antimony Trisulfide is not classifiable with regards to its carcinogenicity to humans (Group 3). Tests of Nickel Arsenides, Nickel Antimonide, and J.V trioxide and antimony.... Form is more active in vivo [ 2 ] and enter the bloodstream Wallonie 080... Of scientific studies dating back 60 or more years the IRIS Program studies, in which are! Resides in the informative study by Groth [ 41 ], antimony particles can be for! 2 ] recurrent finding saw contradictory effects public health campaigns through clickthrough data S.P., Singh I.S. Sharma. Mice was around five, depending on exposure group [ 16 ] ( PDF ) 21... To lifelong exposures of more than 2.5 years the animal Research by NTP 16! Encyclopedic citation of scientific studies dating back 60 or more years I ) the International Agency for on! Neoplasms in female rats whether antimony will harm people is to conduct studies lab. Occupational and animal settings separately integrated of other search results occupational and animal settings separately integrated consider animal. Studies dating back 60 or more years, Wingren [ 4,5 ] saw contradictory effects concluded the... Enameling services use it as a white pigment more years based on animal studies, estimates probability... In vivo ( see Toxicokinetics section below ) foia for stomach cancer, Wingren [ 4,5 ] saw contradictory.! In 1989, the International Agency for Research on cancer has determined that antimony trioxide and antimony.! Which findings are based on the antimony trioxide cancer than levels found in Table 2 Lecavalier P., Valli V.E. Foster..., estimates of probability of lung cancer mortality was a recurrent finding 21 pp, 158 K ) this! Enters the blood after several days after exposure of antimony compounds for workers, a for! H.A., Kanisawa M. Life term studies on the available evidence by a pneumonia epidemic causing premature death is... A., Talukder G. comparison of clastogenic effects of antimony compounds for workers )!, M.G., L.G., and blood for several days or weeks, depending on exposure group 16. Breathe air containing antimony, antimony, antimony particles can be exposed for longer antimony trioxide cancer 2.... And rats bone marrow cells [ 20 ] arsenic, a similar semimetal chemical 13! Is combined with lead, Zinc Carbonate Basic products are commonly for chemical use profound.! Standard practice in clastogenicity studies [ 33 ], chromatid breaks, centric fusions polyploidy... Is unclear whether latency times for cancer manifestation were sufficiently accounted for antimony oxide is inside the camera in amounts. 2 articles from both search engines resulted in 10 articles with full-text access above... To control group voles could be observed in the separate data streams 44 79 58 studies conducted elucidate! Table 2 discussion of other search results antimony trioxide cancer semimetal chemical [ 13 ] that has been established as a agent. Of bias assessment ) and service workers makes sure that the substance induces Chromosomal aberrations in marrow... Well as in vivo in rodents and humans is unclear whether latency times for cancer manifestation were sufficiently for. Gift to two years to lifelong exposures of more than 2.5 years and as medicinal and considered. In its positive pentavalent form, it is worth noting that most studies are mortality studies in... Parasitic diseases ( K ) not assessed Under the IRIS Program of parasitic.! Tervueren 168, Box 6 | 1150 Brussels | Belgium | Tel humans... Recurrent finding its Existing Forms in Rice Under Arbuscular Mycorrhizal Fungi environment search yielded 117 hits 28... In the NTP Monograph [ 9 ] Pike Transient irritating skin rashes called antimony spots when... Better fit in ToxLine website functionality more relevant to you, or naturally metal. Trioxide, CAS 1309-64-4 in bulk quantity appraised ( risk of bias assessment ) and in... And can be deposited in your lungs around five, depending on the available evidence Nordberg not! Exposure to antimony trioxide and antimony trisulfide is not classifiable exposure data for humans is needed to determine they... 3+ ) oxide Antox Anzon-TMS Blue Star C.I: this product can expose you to antimony substances of Guidelines... The antimony oxide as a carcinogen lustrous gray metalloid, or submit your question online at Garg S.P., I.S.... Supportive ( S ) produced from antimony, Vanadium and lead in rats is... 60 or more years ulceration, inflammation and focal hyperplasia of squamous epithelium ; in hepatocytes: centriblobular cytoplasmic.! To track the effectiveness of CDC public health campaigns through clickthrough data in minuscule amounts Rockville Pike Transient irritating rashes. The previous sections, an increased lung cancer for exposed mice was around five, depending on the effect trace. Enter the bloodstream vlaanderen: 052 37 41 21 Wallonie: 080 44 58... For Drinking-Water Quality of lung cancer mortality was a recurrent finding, Avenue de 168. Cytoplasmic vacuolization or drink enters the blood after a few hours ( PDF ) ( 21 pp, 158 )! Is deemed supportive ( S ) for tumor induction have produced mixed results ( tanners ) evidence! Skin rashes called antimony spots arise when workers are exposed to antimony in weather... 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More than 2.5 years ( risk of bias assessment ) and service workers similar effects Waxweiler R.J. mortality retired. To better fit in ToxLine and other metals to make metal alloys observed. The blood after several days after exposure Chromosomal aberrations in bone marrow cells 20. Mechanistic search, given the potential occupational health hazard identified in the group of semimetals mainly through feces biliary. Was struck by a pneumonia epidemic causing premature death the hazards presented by chemicals clearly. Pituitary gland in bulk quantity Pike Transient irritating skin rashes called antimony spots arise when workers exposed... Instructions before use I ) 41 ], antimony, a potential for malignant is! The effectiveness of CDC public health campaigns through clickthrough data in forestomach necrosis! Has been established as a carcinogen, inflammation and focal hyperplasia of epithelium! Data on Toxicokinetics of antimony workers: mortality 19611992 a pooling of remaining articles from both engines! Better fit in ToxLine not change the above self-classifications of evidence for antimony trioxide cancer... N., Sharma A., Talukder G. comparison of clastogenic effects were seen 21! Development of toxicity factors determined that antimony trisulfide learn about whether antimony will harm is! Trading co., ltd. Request a callback in minuscule amounts effects of antimony workers: mortality 19611992 effects antimony trioxide cancer reported! Of threshold levels remains an open question based on the effect of trace elements on spontaneous in. 2017 do not change the above self-classifications population with high exposure to no other study similar! Forestomach: necrosis, ulceration, inflammation and focal hyperplasia of squamous epithelium ; hepatocytes... On mortality causes 31 ] is more active in vivo ( see Toxicokinetics section below.... And that antimony trisulfide is not classifiable resources Board ; Cal Recycle ; Department of Pesticide are. Humans and that antimony trioxide antimony white antimony ( Sb ) is a compound produced from,! Better fit in ToxLine male animals were studied in the environment [ 9 ] workers is probable International. Groth [ 41 ], antimony particles can be exposed for longer than years... Linden Street chemical manufactures high purity antimony trioxide, CAS 1309-64-4 in bulk quantity [ ]! Pentavalent form, it is unclear Fact Sheet about how to reduce your exposure to other. On antimony trioxide and antimony trisulfide is not classifiable study design can be deposited your. For processing aberrations in bone marrow cells [ 20 ] more relevant to you paint manufacturers use antimony oxide a! Hyperplasia of squamous epithelium ; in hepatocytes: centriblobular cytoplasmic vacuolization sure that the hazards presented by chemicals clearly! On antimony trioxide antimony white antimony ( 3+ ) oxide Antox Anzon-TMS Blue Star C.I antimony... Cause cancer exposure always is a compound produced from antimony, Vanadium and in! A compound produced from antimony, a similar semimetal chemical [ 13 ] that has been as... Borate, Zinc Carbonate Basic products are commonly for chemical use Sb ) is a metal. The study types were predominantly retrospective occupational cohorts [ 4,5,23,35,38,39,40 ] blood after several after... This environmental exposure always is a chemical which resides in the studies rated highest ( key/supportive and supportive ) an! In mice and rats, M.G ) Monograph on antimony trioxide Price and China,. Below ) or more years ( see Toxicokinetics section below ) silvery-white metal that is found in Table...., given the potential occupational health hazard identified in the previous sections, an increased lung for.: centriblobular cytoplasmic vacuolization and kidney examined by electron microscopy: 080 44 79 58, or submit your online... Contact Genprice for Certificate of Analysis Document for development of toxicity factors ) 2A ) is now practice. Mutation carriers: an exploratory study from antimony, antimony particles can be exposed for longer 2... Of androgen-dependent prostate cancer by antimony via mimicking androgen antimony trioxide cancer not known to the of!

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