Brilliant Blue FCF, CAS No. 1 was approved in various countries to be used as a food additive in dairy products, candies, cereals, cheese, toppings . An uncertainty factor of 100 seems to have been applied. The second group was treated for 15 days, the third group 1 Fenazo Blue XI Food Blue No. 4, Alzen Food Blue No. They can be found mainly in ice creams and other dairy products, peas, and drinks. In . non-toxicity, and accurate composition. Neptune Blue Bra Concentration. The WHO acceptable daily intake is . Comments Off on Toxicity Profile for Brilliant Blue FCF (1999) Brilliant Blue FCF was irritating to the skin of humans and to the eyes of rabbits. BRILLIANT BLUE FCF . Neptune Blue BRA. Brilliant Blue FCF has been previously evaluated by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) in 1970 and the EU Scientific Committee for Food (SCF) in 1975. This dye is toxic to a Welch's wrasse at a concentration of 13 mg/L. 1 Japan Blue 1 Merantine Blue EG Cosmetic Blue Lake. Brilliant Blue FCF, Erioglaucine disodium, Green S or Lissamine Green B, and Fast Green FCF are synthetic triarylmethane dyes. Colaba, Mumbai, Maharashtra India View Mobile . Prepared at the 84th JECFA and published in JECFA Monograph 20 (2017) superseding specifications prepared at the 28th JECFA (1984) and published in FNP 31/1 (1984) and in FNP 52 (1992). These surgical skin markers impair functional responses of the HSV tissue. : 3844-45-9 1.2 Relevant identified uses of the substance or mixture and uses advised against . Company Details. MedChem Express HY-D0915. 1 Atracid Blue FG Blue #1 Lake Erioglaucine Eriosky blue Patent Blue AR Xylene Blue VSG C.I. The Panel on Food Additives and Nutrient Sources added to Food provides a scientific opinion re-evaluating the safety of Brilliant Blue FCF (E 133). Chronic toxicity of brilliant blue FCF, blue VRS, and green S in rats * Chronic toxicity of brilliant blue FCF, blue VRS, and green S in rats * MANNELL, W. A.; GRICE, H. C. 1964-01-01 00:00:00 Groups of twenty rats were given weekly subcutaneous injections of one of the food colours Brilliant Blue FCF, Blue VRS, and Green S. The dose, 20 mg in isotonic saline, was given for 45 weeks after . In general, toxicity is a factor that must be thoroughly assessed and evaluated, to ensure health and safety [2,5,10]. Chronic toxicity and carcinogenicity: J. F. Borzelleca et al., Food Chem. An ADI of 0-6 mg/kg bw was established at the 84th JECFA (2017). Brilliant Blue FCF, analytical standard. Metals and arsenic specifications revised at the 59th JECFA (2002). Importance: Surgical skin markers are used off-label to mark human saphenous veins (HSVs) to maintain orientation before implantation as aortocoronary or peripheral arterial bypass grafts. 1 or acid blue 9. It is a triphenylmethane colour. It is denoted by E number E133 and has a color . If one Blue Raspberry hard candy contains 56.9 x 10g of Brilliant Blue FCF, what is the maximum number of Blue Raspberry hard candies that can be dropped into a 19.8 L fish tank before the Brilliant blue FCF (FCF) is a nontoxic dye alternative that may also ameliorate preparation-induced injury.Porcine saphenous vein (PSV) was used to evaluate the effect of FCF on physiologic responses in a muscle bath. clearly demonstrates the toxic effect of Brilliant blue FCF on both plant as well as the human DNA. indicator 0.1% water solution were purchased from Aldrich Examples of degradation patterns that employ photocatal- (Milwakee, WI, USA), potassium dichromate and . The dye showed no toxicity on crustacean (CL50/CE50]100mg/L) before ozonation. Contact Technical Service for further support. 12.1 Toxicity Aquatic toxicity Acute (short-term) fish toxicity Parameter : LC50 ( Brilliant blue FCF (C.I. Interested in this product? Metals and arsenic specifications revised at the 59th JECFA (2002). Brilliant Blue FCF is a synthetic blue dye derived from petroleum. 12.1 Toxicity Aquatic toxicity Acute (short-term) fish toxicity Parameter : LC50 ( Brilliant blue FCF (C.I. Body systems harmed by brilliant blue FCF. Brilliant blue FCF (FCF) is a nontoxic dye alternative that may also ameliorate . Maple Brilliant Blue FCF. It is a synthetic dye produced using aromatic hydrocarbons from petroleum, is a colorant for foods and other substances. Molecular Weight. Properties: Reddish-violet powder or granules with a metallic lustre. SYNONYMS Brilliant blue FCF has been used as a test compound in validating the lowest observed adverse effect level (LOAEL) to inflict developmental toxicity upon exposure to common excipients. Customers must be at least 21 years old to order this product, and must possess the knowledge regarding toxicity, health hazards, and all regulations required to . According to the higher level of intake of these dyes (Table 1 ), some adults may be above the ADI of Brilliant Blue FCF and Green S. BRILLIANT BLUE FCF MSDS CAS: - 3844-45-9 Section 1: Chemical Product and Company Identification Section 1: Chemical Product Product Name: BRILLIANT BLUE FCF CAS#: -3844-45-9 C.I. Brilliant Blue FCF has the appearance of a reddish-blue powder. Know about technical details of brilliant blue FCF like: chemical name, chemistry structure, formulation, uses, toxicity, action, side effects and more at Pharmacompass.com. Brilliant Blue FCF has the appearance of a reddish-blue powder. The literature suggests that there is no carcinogenicity or mutagenicity to rodents. It is denoted by E number E133 and has a color index of 42090. Thirty rats were used at each feeding level. Properties: Reddish-violet powder or granules with a metallic lustre. Ask for more details & Latest Price from seller. . Product Name: SPECTRACID BRILLIANT BLUE FCF CRUDE Product Number: 5.AC.0009F0 Color Index Name: C.I. CID 17560 (Food Blue 1) Toxicol. Total Number of Employees 50 - 100; Year . Brilliant Blue FCF PubChem CID: 19700 Molecular Formula: C37H34N2Na2O9S3 Synonyms: Brilliant Blue FCF 3844-45-9 Acid Blue 9 Erioglaucine disodium salt Brilliant Blue More Molecular Weight: 792.9 g/mol Dates: Modify: 2020-01-11 Create: 2005-07-19 . Long-term toxicity studies performed on healthy rats and dogs have found no adverse effects; the dye was approved on this basis. . ブリリアントブルーFCF (Brilliant Blue FCF) は、青色に着色することのできる着色料。 食用タール色素に分類される合成着色料である。 通称青色1号（あおいろいちごう）。常温では金属光沢のある赤紫色の粒状の固体で、無臭である。 分子式はC 37 H 34 N 2 Na 2 O 9 S 3 、分子量792.86。 It is soluble in water, and the solution has a maximum absorption at about 628 nanometers. Brilliant Blue and Benzyl Violet had no adverse effects on growth at any of the levels used. BRILLIANT BLUE FCF IS A NON-TOXIC DYE FOR SAPHENOUS VEIN GRAFT MARKING THAT ABROGATES RESPONSE TO INJURY. 2650-18-2; Office of Toxic Substances USEPA Washington DC 19 pages (1981). : 3844-45-9 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, manufacture of substances. Brilliant blue FCF of food color was given in the diets of mice at levels of 0% (control), 0.08, 0.24, and 0.72% from 5 weeks of age in the F (0) generation and continuing to 11 weeks of age in the F (1) generation and selected reproductive and neurobehavioral parameters were measured. A low acute oral toxicity was indicated in rats. L-1 [8]. Brilliant Blue FCF, Indigo carmine, Allura red, carminic acid, Ponceau 4R, Sunset yellow, tartrazine, fast green FCF: Liquid foods: FD&C Blue No.1 Acid Blue 9 D&C Blue No. INTRODUCTION Food coloring. 1, Alphazurine, Atracid Blue FG, Erioglaucine, Eriosky blue, Patent Blue AR, Xylene Blue VSG, and C.I. Metals and arsenic specifications revised at the 59th JECFA (2002). The BB FCF toxic effect, before and after ozonation was investigated on crustacean (Daphnia magna), lethal or inhibitory concentrations for 50% of tested organisms (LC50 / EC50) were used to estimate the effect level. An ADI of 0-12.5 mg/kg bw was established at the 13th JECFA (1969). Know about technical details of brilliant blue FCF like: chemical name, chemistry structure, formulation, uses, toxicity, action, side effects and more at Pharmacompass.com. S D International offers Brilliant Blue FCF well known for using superior purity chemicals to meet International Industry standards. Brilliant Blue FCF (C.I. Objectives: To investigate the effect of brilliant blue dye 1 (brilliant blue FCF [for food coloring]; hereinafter, FCF) as a . A color additive, as defined by regulation, is any dye, pigment, or other substance that can impart color to a food, drug, or . 275 / Kilogram Get Quote. On the other hand, FD&C Blue No. It is a blue powder which is soluble in water. Brilliant Blue FCF is an approved food colourant in the EU and it is listed in Annex I of Directive 94/36/EC9 of 30 June 1994. : HY-D0915 CAS No. Brilliant Blue FCF is an approved food colourant in the EU and it is listed in Annex I of Directive 94/36/EC9 of 30 June 1994. In 1984, the . for a period of 13 weeks followed by . 42090) ; CAS No. Brilliant blue FCF can cause harm to the deoxyribonucleic acid (DNA) and many genotoxic effects in mammalian cells. Product Description. 1 or acid blue 9. Health considerations. chronic toxicity of brilliant blue fcf, blue vrs, and green s in rats j pharm pharmacol. It has the appearance of a blue powder and is soluble . Brilliant blue FCF (Blue 1) is a synthetic organic compound used primarily as a blue colorant for processed foods, medications, dietary supplements, and cosmetics. or. Chemical Formula: C37H34N2O9S3Na2 Brand: OXFORD The degradation is studied in oxidation conditions obtained by addition of potassium persulfate at different persulfate to dye molar ratios under natural sunlight irradiation. NSC 4318. Brilliant blue FCF has been used as a test compound in validating the lowest observed adverse effect level (LOAEL) to inflict developmental toxicity upon exposure to common excipients. According to the same Directive Brilliant Blue FCF is an allowed synthetic food colouring substance in the EU with a maximal allowed use level of 20-500 mg/kg food for various foodstuffs. Growth inhibition occurred in the male animals fed Indigotine at the 2.0 and 5.0% levels. 11-101-4100. Question 3 4 pts Many popular blue candies are colored with a dye called Brilliant Blue FCF. Product name : BRILLIANT BLUE FCF Product Number : 80717 Brand : Sigma-Aldrich CAS-No. Brilliant Blue FCF is a synthetic blue dye derived from petroleum. CID 17560 (Food Blue 1) Component Compounds. Synonyms. Both committees established an ADI of 12.5 mg/kg bw/day. FD&C Blue No. View all products in Brilliant Blue Fcf. There was ulceration and abscess formation at the site of injection in rats given Blue VRS. : 3844-45-9 ) Species : Oncorhynchus mykiss (Rainbow trout) Evaluation parameter : Acute (short-term) fish toxicity Effective dose : 412 mg/l Exposure time : 96 hour(s) Acute (short-term) toxicity to crustacea : 3844-45-9 ) Species : Oncorhynchus mykiss (Rainbow trout) Evaluation parameter : Acute (short-term) fish toxicity Effective dose : 412 mg/l Exposure time : 96 hour(s) Acute (short-term) toxicity to crustacea Function Food colorant CI Number 4 2 090:2 CI Name Food Blue 2:2 Brilliant Blue FCF (dikenal juga sebagai FD&C Blue No.1, Food Blue 2, Acid Blue 9, D&C Blue No. BRILLIANT BLUE FCF Prepared at the 28th JECFA (1984), published in FNP 31/1 (1984) and in FNP 52 (1992). C37H37N2Na2O9S3+. Toxicol. . L-1 [8]. The effects of operatioanl parameters such as pH, contact time, temperature and dye concentration were studied in the case of Brilliant Blue FCF removal by sorption on unmodified natural clay and modified with iron chloride [9]. More recent studies on mice and rats found toxicity to be concentration dependent, with a no-observed-effect level of 0.5% of the dye in the diet. Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. 42090) is a colorant that may be added to foods and other substances to induce a color change.It is denoted by E Number E133.It has the appearance of a reddish-blue powder. : BP100-25; BP100-50 CAS No 6104-58-1 Synonyms Acid Blue 90; Coomassie Blue; Brilliant Blue G 250 Recommended Use Laboratory chemicals. The ozonized solutions presented a high toxicity . It is an artifical dye produced from petroleum. It is classified as a triarylmethane dye and is known under various names, such as FD&C Blue No. Shade Food Colours. Organism Test Type Route Reported Dose (Normalized Dose) Effect Source; human: LDLo: intravenous: 33ug/kg (0.033mg/kg) S D International is committed to customer fulfillment by delivering the best quality Dyes, Pigments . SYNONYMS pmid: 14106566 . Molecular Weight. Brilliant Blue FCF (Blue 1) is a synthetic organic compound used primarily as a blue colorant for processed foods, medications, dietary supplements, and cosmetics.wikipedia. It is used in soaps, shampoos, hair color, mouthwash and other hygiene and cosmetics applications. Available in several packaging options, our quality analysts strictly test our provided colors on various parameters to ensure their quality. No effect was observed on survival, hematology, or organ weights. 42090) ; CAS No. It is soluble in water, and the solution has a maximum absorption at about 628 nanometers. Chronic toxicity and carcinogenicity: J. F. Borzelleca et al., Food Chem. Acute toxicity Animal Route LD 50 Reference mg/kg body weight Mouse Subcutaneous 4 600 Gross, . Brilliant Blue FCF [MeSH: brilliant blue FCF] Alphazurine FG FD & C Blue no. 1, Alphazurine, Atracid Blue FG, Erioglaucine, Eriosky blue, Patent Blue AR, Xylene Blue VSG, dan C.I. Triphenylmethane dyes are composed of three hydrocarbon rings linked to a central carbon atom 1. Kyle M. Hocking . BRILLIANT BLUE FCF IS A NON-TOXIC DYE FOR SAPHENOUS VEIN GRAFT MARKING THAT ABROGATES RESPONSE TO INJURY. . This paper is devoted to the evaluation of the degradation pathway of the E133 Brilliant Blue FCF (C.I. Since most dyes currently used for microbial fluorescent staining are toxic or carcinogenic, a tissue array system using brilliant blue FCF, which is a food dye and thus has no toxic effects, was . Brilliant blue FCF has been used as a test compound in validating the lowest observed adverse effect level (LOAEL) to inflict developmental toxicity upon exposure to common excipients. SAFETY DATA SHEET Creation Date 31-Oct-2011 Revision Date 24-Dec-2021 Revision Number 4 1. Product name : Brilliant Blue FCF Catalog No. Synonym: Brilliant blue FCF, Acid Blue 9; Erioglaucine Chemical Name: Not available. Most natural blue dyes are either unstable, blue only in alkaline conditions, or toxic; good candidates for further research into use as natural dyes include . Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Buy high-quality Brilliant Blue FCF from S D International - leading exporter and supplier of Brilliant Blue FCF CAS (3844-45-9) are known for its high quality. It is a synthetic dye produced using aromatic hydrocarbons from petroleum, is a colorant for foods and other substances. 4, Alzen Food Blue No. Keywords: Food colours, Optical Density, Brilliant Blue FCF, Denaturation, Renaturation. Clients can avail these Brilliant Blue FCF from us at reasonable rates. Reprinted from Food Safety Magazine October/November 2003 issue. 2) were fed to groups of 24 Osborne-Mendel rats for two years at dietary levels of 0.5, 1.0, 2.0, and 5.0%. Brilliant blue FCF (Blue 1) is a synthetic organic compound used primarily as a blue colorant for processed foods, medications, dietary supplements, and cosmetics. The effects of operatioanl parameters such as pH, contact time, temperature and dye concentration were studied in the case of Brilliant Blue FCF removal by sorption on unmodified natural clay and modified with iron chloride [9]. Data available on the absorption, distribution, metabolism and excretion of Brilliant Blue FCF, show that Brilliant Blue FCF is poorly absorbed and mainly excreted unchanged in faeces. 78 Mahmoud (2006) Toxic Effects of The Synthetic Food Dye Brilliant Blue on Liver, Kidney and Testes Functions in Rats supplemented diet of oral dose 0.08 g/kg diet (1/10 dose of Ibrahium et al., 1988a), the other ten rats were daily treated with the dye supplemented diet of oral dose 0.4 g/kg diet). OSHA-Ca (Occupational Safety & Health Administration) Substance is not listed. Review of carcinogenicity studies: IARC Monographs 16, 171-186 (1978). Brilliant Blue FCF. Manufacturer: MilliporeSigma Supelco 80717100MG Catalog No. Application. Mice were mated at 9 weeks of age and dams were delivered . 1) and Indigotine (FD & C Blue No. 792.85. A literature review was carried out to compile data on Brilliant Blue FCF toxicity.
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